By Gia Nevel, PMHNP
Resilience refers to an individual’s capability to persevere through adversity. Resilient individuals adapt and grow from challenges, often becoming stronger in the process. It is a dynamic trait based on many factors, including personality, coping skills, and social support. Resilience is a quality that can be strengthened and is an important component of mental wellness.
Ketamine is thought to support resiliency by enhancing synaptic plasticity. Synaptic plasticity refers to the brain’s ability to reorganize neural networks by strengthening or weakening the connections between neurons. Synaptic plasticity supports the brain’s ability to adapt to new situations, learn from various experiences, and recover from trauma. It is regarded as a key aspect of human resilience and transformative potential. However, under prolonged stress, areas relating to cognitive function and emotional systems may weaken due to synaptic plasticity. In vulnerable individuals, this process can increase susceptibility to psychiatric disorders. For instance, in depression, regions in the brain associated with self-awareness and attention may become imbalanced, manifesting as feeling disconnected from others and negative cognitive biases.
Ketamine has the unique ability to positively influence synaptic plasticity rapidly. Current research suggests that Ketamine strengthens the connections of neurons in areas relating to our higher-level thinking in our prefrontal cortex and dampens the heightened stress response circuitry. By amplifying the brain’s resilience to stress, ketamine can reduce the likelihood and intensity of future depressive episodes. This enhanced resilience might explain why numerous individuals experience benefits long after concluding ketamine therapy.1
If you or your loved one are suffering with depression, ketamine therapy may be a great next step for you. Feel free to call Kure Medical or your local ketamine center to learn more about ketamine infusion therapy. If this is an emergency please call the National Mental Health Hotline: 988 or call the National Emergency Hotline: 911
Disclaimer: This blog is for informational purposes only and does not constitute medical advice. Please consult with a healthcare professional for personalized recommendations and guidance regarding ketamine therapy.
- Hyde, Dr. Stephen J.. Ketamine for Depression (p. 184). Xlibris AU. Kindle Edition. ↩︎