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How Ketamine Therapy Supports Resilience

By Gia Nevel, PMHNP

Resilience refers to an individual’s capability to persevere through adversity. Resilient individuals adapt and grow from challenges, often becoming stronger in the process. It is a dynamic trait based on many factors, including personality, coping skills, and social support. Resilience is a quality that can be strengthened and is an important component of mental wellness.

Ketamine is thought to support resiliency by enhancing synaptic plasticity. Synaptic plasticity refers to the brain’s ability to reorganize neural networks by strengthening or weakening the connections between neurons. Synaptic plasticity supports the brain’s ability to adapt to new situations, learn from various experiences, and recover from trauma. It is regarded as a key aspect of human resilience and transformative potential. However, under prolonged stress, areas relating to cognitive function and emotional systems may weaken due to synaptic plasticity. In vulnerable individuals, this process can increase susceptibility to psychiatric disorders. For instance, in depression, regions in the brain associated with self-awareness and attention may become imbalanced, manifesting as feeling disconnected from others and negative cognitive biases. 

Ketamine has the unique ability to positively influence synaptic plasticity rapidly.  Current research suggests that Ketamine strengthens the connections of neurons in areas relating to our higher-level thinking in our prefrontal cortex and dampens the heightened stress response circuitry. By amplifying the brain’s resilience to stress, ketamine can reduce the likelihood and intensity of future depressive episodes. This enhanced resilience might explain why numerous individuals experience benefits long after concluding ketamine therapy.1


If you or your loved one are suffering with depression, ketamine therapy may be a great next step for you. Feel free to call Kure Medical or your local ketamine center to learn more about ketamine infusion therapy. If this is an emergency please call the National Mental Health Hotline: 988 or call the National Emergency Hotline: 911 

Disclaimer: This blog is for informational purposes only and does not constitute medical advice. Please consult with a healthcare professional for personalized recommendations and guidance regarding ketamine therapy.

  1. Hyde, Dr. Stephen J.. Ketamine for Depression (p. 184). Xlibris AU. Kindle Edition. ↩︎
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Kure Medical Group

Valentina Ira, MSN, PMHNP-BC

Psychiatric Nurse Practitioner

Valentina is a board certified Psychiatric Mental Health Nurse Practitioner dedicated to treating depression, anxiety, addictions, PTSD, and trauma. She has 14+ years of experience in healthcare with specialties in addiction medicine, psychiatry and mental health, as well as emergency department, surgery, and oncology. She received post-graduate degree in Psychiatric Mental Health at Rocky Mountain University of Health Professions in Utah. She is a Clinical Faculty at Moorpark College nursing program and a Nurse Practitioner at Los Angeles addiction treatment centers. Valentina believes in the integrative approach that mergers best of Western and Eastern medicine and she has a holistic view on healing all aspects of life that contribute to mental illness. She believes that each client is unique so every treatment plan should be uniquely tailored to that individual; her goal is also to make clients feel accepted and safe. Valentina has been practicing transcendental meditation, yoga, and Ayurvedic lifestyle for many years. She enjoys living in the Santa Monica Mountains and hiking local trails.

Steve Yun, M.D.

Anesthesiologist | Medical Director

Dr. Yun is Board-Certified by the American Board of Anesthesiology and Certified in Adult and Pediatric Advanced Life Support. He received his B.S. with Honors from the University of Wisconsin-Madison, and his M.D. with Honors from the University of Southern California in 1996, followed by three years of additional training in Anesthesiology at the UCLA Medical Center. He has been in private practice since 2000. For the last 15+ years, he has served as Director of Anesthesia for Dr. Daniel Kharrazi, – Former Team Physician for the Los Angeles Lakers. ​Dr. Yun is a Clinical Professor at Western University of Health Sciences and a Lecturer at the Loma Linda School of Dentistry. He has received the Physician of Excellence Award multiple times from the Orange County Medical Association. He has been recognized as “Anesthesiologist of the Year” by the Fresh Start Surgical Charity and is a proud supporter of the So Cal Bulldog Rescue Organization.

Andy Rimando, MSN, PMHNP-BC

Psychiatric Nurse Practitioner

Andy has built a solid experience in health care in the last 18 years, with specialties in sleep medicine, critical care, anesthesia and post anesthesia care, as well as psychiatry and mental health. He graduated from California State University Los Angeles, and attended schools in University of Scranton in Pennsylvania, and Stevenson University in Maryland. He completed his nursing residency in Johns Hopkins Hospital in Baltimore, and has worked in University of Maryland Medical Center, Penn State Hershey Medical Center, Cedars Sinai Medical Center, and recently at Kaiser Permanente in Oakland. He loves to hike big mountains in his free time, and has traveled to several countries to experience other cultures. He currently resides in Los Angeles California.

Janet Sharma, MSN, PMHNP-BC

Medical Advisor

Janet is a board-certified psychiatric mental health nurse practitioner focused on treating anxiety, depression, and women’s mental health. She believes that inner work is critical to one’s mental health journey, as it helps solidify new views and coping skills.  Janet has experience doing critical care in the emergency department. She has also worked with patients in inpatient and outpatient mental health settings. She has worked with individuals from diverse backgrounds across all age groups using a holistic therapeutic model. She is passionate about restoring personal health and wellness. Janet understands that growth is not linear and that the ability to change remains with us. Janet enjoys teaching and learning from others, spending time with her family, and learning new things along the way. She is also fluent in Spanish.

Erica Weiszmann

Office Manager

Erica’s passion for healthcare stems from the insatiable curiosity she has for humans and her belief that everyone deserves freedom from the chains of mental illness. She became immersed in the world of mental health afflictions during employment as a pre-medical student, and this interest extended into a desire to assist all kinds of patients in accessing the most appropriate mental health resources for them.  She has seen the positive and frankly, life-changing, effects of ketamine treatment firsthand during her time as a medical assistant at a clinic providing infusions for individuals with treatment-resistant depression and chronic pain.  She is proud to be serving the community of southern California with the services here at KureKetamine as Business Office Manager.  Armed with an extensive background in behavioral health to best complement the care you receive here, she holds certifications in Brain Health, as well as Meditation.  When she is not working, you can catch her at hot yoga, biking through LA, body surfing at the incredible beaches here, trying out a new Pinterest recipe, and reading about neuroscience.

Steve Yun, M.D.

Anesthesiologist | Medical Director

Dr. Yun is Board-Certified by the American Board of Anesthesiology and Certified in Adult and Pediatric Advanced Life Support. He received his B.S. with Honors from the University of Wisconsin-Madison, and his M.D. with Honors from the University of Southern California in 1996, followed by three years of additional training in Anesthesiology at the UCLA Medical Center. He has been in private practice since 2000. For the last 15+ years, he has served as Director of Anesthesia for Dr. Daniel Kharrazi, – Former Team Physician for the Los Angeles Lakers. ​Dr. Yun is a Clinical Professor at Western University of Health Sciences and a Lecturer at the Loma Linda School of Dentistry. He has received the Physician of Excellence Award multiple times from the Orange County Medical Association. He has been recognized as “Anesthesiologist of the Year” by the Fresh Start Surgical Charity and is a proud supporter of the So Cal Bulldog Rescue Organization.

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